Postanoxic electrographic status epilepticus and serum biomarkers of brain injury

AimTo explore if electrographic status epilepticus (ESE) after cardiac arrest causes additional secondary brain injury reflected by serum levels of two novel biomarkers injury: neurofilament light chain (NfL) originating from neurons and glial fibrillary acidic protein (GFAP) cells.MethodsSimplified continuous EEG (cEEG) NfL GFAP, sampled at 24, 48 72 h arrest, were collected during the Target Temperature Management (TTM)-trial. Two statistical methods used: multivariable regresssion analysis; a matched control group patients without ESE for early predictors poor neurological outcome.Results128 had available cEEG. Twenty-six (20%) developed ESE, majority (69%) within 24 h. was an independent predictor elevated (p < 0.001) but not GFAP = 0.16) arrest. Compared to outcome, who higher 0.03) 0.04) arrest.ConclusionESE is associated with which may suggest increased neuronal compared similar initial injury. Associations reflecting are less clear. The study design cannot exclude imperfect matching or other mechanisms contributing seen in ESE.